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The production of glycerol leads to restoration of turgor and hence stops further activation of the pathway.

Model for the mechanisms with which the HOG pathway controls gene expression via Sko1p.

Rav Z initially recognizes the LC3 molecule on membranes via its N-terminal LC3-interacting region (LIR) motif.

The Rav Z α3 helix is involved in extraction of the PE moiety and docking of the acyl chains into the lipid-binding site of Rav Z that is related in structure to that of the phospholipid transfer protein Sec14.

However, it is now recognized that controlled production of ROS has significant signaling functions, for example, in pathogen defense, in the regulation of stomatal closure, or in cell-to-cell signaling.

ROS formation in subcellular compartments is critical to act as “alarm” signal in the response to stress, and the concept of ROS as primarily signaling substances has emerged.

Thus, Legionella has evolved a novel mechanism to specifically evade host autophagy.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Outline of the yeast MAP kinase pathways, illustrating similarities and difference in architecture.

Gpa1p, Ste4p, and Ste18p form a heterotrimeric G-protein; Ras2p is one of two yeast Ras proteins. Possible mechanism of feedback control of the HOG pathway, indicating protein phosphatases whose production is stimulated after osmotic shock.

The involvement of ROS in several developmental and inducible processes implies that there must be coordinated function of signaling network(s) that govern ROS responses and subsequent processes.

The air pollutant ozone can be used as a useful tool to elucidate the function of apoplastic ROS: O degrades in cell wall into various ROS which are interpreted as ROS with signaling function inducing downstream responses.

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